MM.1S ATCC ® CRL-2974™ Homo sapiens peripheral blood immunog, MM.1S: A model for multiple myeloma – Covance, Characterization of the MM.1 human multiple myeloma (MM) cell lines:.
MM.1S: A model for multiple myeloma – Covance, To further optimize the MM.1S-pMMP-LucNeo model, we characterized growth in the NSG mouse strain which shows more aggressive disease onset (staging seven days post implant vs. 15 days in SCID mice). In NSG mice, the tumor volume doubling time is ~1.8 days (Figure 4) and median time to endpoint is ~21 days, roughly half the overall survival time observed in the SCID beige mouse.
Population Doubling Time approximately 72 hours Name of Depositor, 4/1/2003 · Thus, unlike other MM cell lines such as RPMI-8266, U-266, OPM-1, and OPM-2, the MM.1 cells do not have complex nutritional requirements [1]. The cells have a doubling time of 72 hours and grow best at high density. These growth characteristics appear to be consistent with those of other myeloma cell lines [2].
nutritional requirements [1]. The cells have a doubling time of 72 hours and grow best at high density. These growth characteristics appear to be consistent with those of other myeloma cell lines [2]. Morphological and biochemical characteristics of MM.1 The.
10/15/2007 · The results showed that whereas the doubling time for the control clone, pU1-C6, did not significantly vary from the ?40 h MM.1S doubling time, the doubling time for both MET ribozyme clones, MM.D6 and MM.F2, were significantly prolonged to 1.29 (P = 0.003) and 1.66 (P = 0.014) times longer, respectively. These results indicate that MM cells with lower levels of MET grow at a slower rate.
12/2/2016 · Furthermore, MM.1S bright cells had a shorter doubling time than both MM.1S dim (p=0.0001) and MM.1R (p=0.048) . This was underscored by an increased proportion of MM.1S bright cells in S-phase coupled with shorter mean telomere length when compared with MM.1S dim and MM.1R (2.58 Kb v 3.29Kb v 3.2Kb respectively).
The cells have a doubling time of 72 hours and grow best at high density. These growth characteristics appear to be consistent with those of other myeloma cell lines, 12/15/2017 · The median tumor volume doubling time is ~2 days and median time to morbidity/mortality endpoint is 35-45 days. MM. 1S -pMMP-LucNeo was also evaluated in NSG mice which show more aggressive disease onset (staging 7 days post implant vs. 15 days in SCID mice).
significantly vary from the f 40 h MM.1S doubling time, the doubling time for both MET ribozyme clones, MM.D6 and MM.F2, were significantly prolonged to 1.29 ( P = 0.003) and 1.66 ( P = 0.014), They have a rapid doubling time of 24-72 hours and are therefore very easy to culture. But for all these reasons, they do not accurately resemble most human myeloma cells, which are typically very difficult to culture outside of human BM.
